HIV/SIV infection primes monocytes and dendritic cells for apoptosis.

HIV/SIV infection primes monocytes and dendritic cells for apoptosis.

Blog Article

Subversion or exacerbation of antigen-presenting cells (APC) death modulates host/pathogen equilibrium.We demonstrated during in vitro differentiation of monocyte-derived macrophages Long Sleeve Polo and monocyte-derived dendritic cells (DCs) that HIV sensitizes the cells to undergo apoptosis in response to TRAIL and FasL, respectively.In addition, we found that HIV-1 increased the levels of pro-apoptotic Bax and Bak molecules and decreased the levels of anti-apoptotic Mcl-1 and FLIP proteins.To assess the relevance of these observations in the context of an experimental model of HIV infection, we investigated the death of APC during pathogenic SIV-infection in rhesus macaques (RMs).

We demonstrated increased apoptosis, during the acute phase, of both peripheral blood DCs and monocytes (CD14(+)) from SIV(+)RMs, associated with a dysregulation in the balance of B12 FOLATE pro- and anti-apoptotic molecules.Caspase-inhibitor and death receptors antagonists prevented apoptosis of APCs from SIV(+)RMs.Furthermore, increased levels of FasL in the sera of pathogenic SIV(+)RMs were detected, compared to non-pathogenic SIV infection of African green monkey.We suggest that inappropriate apoptosis of antigen-presenting cells may contribute to dysregulation of cellular immunity early in the process of HIV/SIV infection.